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Literature summary extracted from
- Plasma proprotein convertase subtilisin-kexin type 9 is predominantly related to intermediate density lipoproteins (2014), Clin. Biochem., 47, 679-682.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.61 | low density lipoprotein receptor + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.61 | Homo sapiens | Q8NBP7 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.61 | plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.61 | low density lipoprotein receptor + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.61 | PCSK9 | - |
Homo sapiens |
| 3.4.21.61 | plasma proprotein convertase subtilisin-kexin type 9 | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.61 | physiological function | proprotein convertase subtilisin-kexin type 9 is a key regulator of low density lipoprotein receptor processing, and affects especially intermediate density lipoproteins. The enzyme pathway may affect plasma triglycerides via effects on the metabolism of triglyceriderich LDL particles | Homo sapiens |
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Release 2023.1 (January 2023)
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